Assay Detail
Functional
CHEMBL1768790
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Antiproliferative activity against human F-36P cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | F-36P |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.41 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765750 | — | — | 1 | 6.72 |
| CHEMBL1765740 | — | — | 1 | 6.55 |
| CHEMBL1765743 | — | — | 1 | 6.41 |
| CHEMBL1765738 | — | — | 1 | 6.34 |
| CHEMBL1765744 | — | — | 1 | 6.34 |
| CHEMBL1614777 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765750 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1765740 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1765743 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1765738 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1765744 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1614777 | — | IC50 | = | 820.0 | nM | 6.09 |