Assay Detail
Functional
CHEMBL1769558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.32 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766208 | — | — | 1 | 8.74 |
| CHEMBL1766204 | — | — | 1 | 8.64 |
| CHEMBL200199 | BIPHALIN | — | 1 | 8.57 |
| CHEMBL1766206 | — | — | 1 | 8.06 |
| CHEMBL1766207 | — | — | 1 | 8.06 |
| CHEMBL1766205 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766208 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1766204 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL200199 | BIPHALIN | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1766206 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1766207 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1766205 | — | IC50 | = | 14.0 | nM | 7.85 |