Assay Detail
Functional
CHEMBL1769559
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.54 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.06 |
| CHEMBL1766208 | — | — | 1 | 7.72 |
| CHEMBL1766206 | — | — | 1 | 7.66 |
| CHEMBL1766207 | — | — | 1 | 7.64 |
| CHEMBL1766204 | — | — | 1 | 7.17 |
| CHEMBL1766205 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1766208 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1766206 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1766207 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1766204 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1766205 | — | IC50 | = | 110.0 | nM | 6.96 |