Assay Detail
Functional
CHEMBL1769563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mu opioid receptor expressed in mouse HN9.10 cells assessed as [35S]GTPgammaS binding
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.41 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766204 | — | — | 2 | 9.24 |
| CHEMBL1766207 | — | — | 2 | 9.14 |
| CHEMBL1766206 | — | — | 2 | 9.08 |
| CHEMBL1766205 | — | — | 2 | 8.10 |
| CHEMBL1766208 | — | — | 2 | 7.54 |
| CHEMBL38874 | DAMGO | — | 2 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766204 | — | EC50 | = | 0.5754 | nM | 9.24 |
| CHEMBL1766204 | — | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1766207 | — | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL1766206 | — | EC50 | = | 0.8318 | nM | 9.08 |
| CHEMBL1766206 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL1766207 | — | EC50 | = | 0.955 | nM | 9.02 |
| CHEMBL1766205 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1766205 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1766208 | — | EC50 | = | 28.84 | nM | 7.54 |
| CHEMBL1766208 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL38874 | DAMGO | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL38874 | DAMGO | EC50 | = | 37.0 | nM | 7.43 |