Assay Detail
Binding
CHEMBL1769806
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Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomes
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Testis |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.35 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766170 | — | — | 1 | 8.08 |
| CHEMBL1765101 | — | — | 1 | 8.00 |
| CHEMBL1766187 | — | — | 1 | 7.85 |
| CHEMBL1766169 | — | — | 1 | 7.82 |
| CHEMBL1766176 | — | — | 1 | 7.77 |
| CHEMBL1766171 | — | — | 1 | 7.72 |
| CHEMBL1766191 | — | — | 1 | 7.72 |
| CHEMBL1766180 | — | — | 1 | 7.62 |
| CHEMBL1766177 | — | — | 1 | 7.62 |
| CHEMBL1766184 | — | — | 1 | 7.60 |
| CHEMBL1766174 | — | — | 1 | 7.55 |
| CHEMBL1766175 | — | — | 1 | 7.54 |
| CHEMBL1766189 | — | — | 1 | 7.48 |
| CHEMBL1766172 | — | — | 1 | 7.48 |
| CHEMBL1766178 | — | — | 1 | 7.31 |
| CHEMBL1766182 | — | — | 1 | 7.28 |
| CHEMBL1766183 | — | — | 1 | 7.21 |
| CHEMBL1766179 | — | — | 1 | 7.15 |
| CHEMBL1766185 | — | — | 1 | 7.09 |
| CHEMBL1766173 | — | — | 1 | 6.92 |
| CHEMBL1766181 | — | — | 1 | 6.68 |
| CHEMBL1766186 | — | — | 1 | 6.50 |
| CHEMBL1766192 | — | — | 1 | 6.35 |
| CHEMBL1766188 | — | — | 1 | 6.11 |
| CHEMBL1766190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766170 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1765101 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1766187 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1766169 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1766176 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1766171 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1766191 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1766180 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1766177 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1766184 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1766174 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1766175 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1766189 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1766172 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1766178 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1766182 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1766183 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1766179 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1766185 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1766173 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1766181 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1766186 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1766192 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1766188 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1766190 | — | IC50 | > | 1000.0 | nM | - |