Assay Detail
Binding
CHEMBL1769807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 17,20 lyase activity
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.30 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766169 | — | — | 1 | 7.75 |
| CHEMBL1766170 | — | — | 1 | 7.72 |
| CHEMBL1766180 | — | — | 1 | 7.68 |
| CHEMBL1766191 | — | — | 1 | 7.66 |
| CHEMBL1766176 | — | — | 1 | 7.62 |
| CHEMBL1766189 | — | — | 1 | 7.58 |
| CHEMBL1766187 | — | — | 1 | 7.58 |
| CHEMBL1766174 | — | — | 1 | 7.57 |
| CHEMBL1766175 | — | — | 1 | 7.55 |
| CHEMBL1766172 | — | — | 1 | 7.48 |
| CHEMBL1766182 | — | — | 1 | 7.44 |
| CHEMBL1766183 | — | — | 1 | 7.42 |
| CHEMBL1766184 | — | — | 1 | 7.40 |
| CHEMBL1766178 | — | — | 1 | 7.36 |
| CHEMBL1766185 | — | — | 1 | 7.35 |
| CHEMBL1766171 | — | — | 1 | 7.31 |
| CHEMBL1766173 | — | — | 1 | 7.27 |
| CHEMBL1766186 | — | — | 1 | 7.11 |
| CHEMBL1766190 | — | — | 1 | 7.04 |
| CHEMBL1766177 | — | — | 1 | 6.92 |
| CHEMBL1765101 | — | — | 1 | 6.89 |
| CHEMBL1766181 | — | — | 1 | 6.82 |
| CHEMBL1766179 | — | — | 1 | 6.80 |
| CHEMBL1766192 | — | — | 1 | 6.62 |
| CHEMBL1766188 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766169 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1766170 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1766180 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1766191 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1766176 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1766189 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1766187 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1766174 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1766175 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1766172 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1766182 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1766183 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1766184 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1766178 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1766185 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1766171 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1766173 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1766186 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1766190 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1766177 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1765101 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1766181 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1766179 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1766192 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1766188 | — | IC50 | = | 340.0 | nM | 6.47 |