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Assay Detail

CHEMBL1769920

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.
Bartalis J, Halaweish FT.
Bioorg Med Chem (2011) 19 : 2757 -2766
PubMed 21459003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.86 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL455056 CUCURBITACIN E 1 7.00
CHEMBL493646 CUCURBITACIN D 1 6.16
CHEMBL507237 CUCURBITACIN B 1 6.10
CHEMBL1765385 1 5.96
CHEMBL1765387 1 5.85
CHEMBL1765517 1 5.50
CHEMBL1765381 1 4.43
CHEMBL1765380 1 -
CHEMBL1765382 1 -
CHEMBL387737 CUCURBITACIN I 1 -
CHEMBL1765383 1 -
CHEMBL1765384 1 -
CHEMBL1765378 1 -
CHEMBL1765379 1 -
CHEMBL1765377 1 -
CHEMBL1765093 1 -
CHEMBL1765386 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL455056 CUCURBITACIN E IC50 = 100.0 nM 7.00
CHEMBL493646 CUCURBITACIN D IC50 = 700.0 nM 6.16
CHEMBL507237 CUCURBITACIN B IC50 = 800.0 nM 6.10
CHEMBL1765385 IC50 = 1100.0 nM 5.96
CHEMBL1765387 IC50 = 1400.0 nM 5.85
CHEMBL1765517 IC50 = 3200.0 nM 5.50
CHEMBL1765381 IC50 = 37000.0 nM 4.43
CHEMBL1765380 IC50 - -
CHEMBL1765382 IC50 - -
CHEMBL387737 CUCURBITACIN I IC50 - -
CHEMBL1765383 IC50 - -
CHEMBL1765384 IC50 - -
CHEMBL1765378 IC50 - -
CHEMBL1765379 IC50 - -
CHEMBL1765377 IC50 - -
CHEMBL1765093 IC50 - -
CHEMBL1765386 IC50 - -