Assay Detail
Functional
CHEMBL1769972
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Antiinflammatory activity against IFN-gamma, TNF-alpha and IL-1-stimulated mouse RAW264.7 cells assessed as inhibition of cellular iNOS synthesis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765578 | — | — | 1 | 6.70 |
| CHEMBL1765576 | — | — | 1 | 5.22 |
| CHEMBL1765577 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765578 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1765576 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1765577 | — | IC50 | = | 17600.0 | nM | 4.75 |