Assay Detail
Binding
CHEMBL1771986
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Inhibition of AChE-induced amyloid beta aggregation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.74 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283509 | — | — | 1 | 9.00 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 8.30 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.22 |
| CHEMBL24686 | TERRITREM B | — | 1 | 8.22 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.27 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.70 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283509 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL24686 | TERRITREM B | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL95 | TACRINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 350.0 | nM | 6.46 |