Assay Detail
Binding
CHEMBL1772003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
6-phosphogluconate dehydrogenase, decarboxylating, putative (CHEMBL1770043) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
Publication
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.10 | 8.00 |
| IC50 | 1 | 5.24 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116018 | — | — | 1 | 8.00 |
| CHEMBL324609 | — | — | 1 | 7.46 |
| CHEMBL114269 | — | — | 1 | 7.10 |
| CHEMBL323922 | — | — | 1 | 5.82 |
| CHEMBL1235136 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116018 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL324609 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL114269 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL323922 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL1235136 | — | IC50 | = | 5800.0 | nM | 5.24 |