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Assay Detail

CHEMBL1772356

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type SH-SY5Y
Confidence 1 — Organism
Curated By Autocuration

Target

SH-SY5Y (CHEMBL614910)
Type CELL-LINE
Organism Homo sapiens

Publication

Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.
Li YP, Ning FX, Yang MB, Li YC, Nie MH, Ou TM, Tan JH, Huang SL, Li D, Gu LQ, Huang ZS.
Eur J Med Chem (2011) 46 : 1572 -1581
PubMed 21367493 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.26 5.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1770210 1 5.67
CHEMBL245472 1 5.49
CHEMBL429291 1 5.41
CHEMBL245471 1 5.38
CHEMBL246911 1 5.34
CHEMBL397782 1 5.27
CHEMBL1770201 1 5.04
CHEMBL1770200 1 4.92
CHEMBL1770204 1 4.79
CHEMBL1770199 1 -
CHEMBL1770198 1 -
CHEMBL1770197 1 -
CHEMBL1770203 1 -
CHEMBL1770202 1 -
CHEMBL1770152 1 -
CHEMBL1770196 1 -
CHEMBL1770205 1 -
CHEMBL1770206 1 -
CHEMBL1770207 1 -
CHEMBL1770208 1 -
CHEMBL1770209 1 -
CHEMBL1770211 1 -
CHEMBL1770212 1 -
CHEMBL1770213 1 -
CHEMBL556249 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1770210 IC50 = 2120.0 nM 5.67
CHEMBL245472 IC50 = 3270.0 nM 5.49
CHEMBL429291 IC50 = 3940.0 nM 5.41
CHEMBL245471 IC50 = 4140.0 nM 5.38
CHEMBL246911 IC50 = 4570.0 nM 5.34
CHEMBL397782 IC50 = 5370.0 nM 5.27
CHEMBL1770201 IC50 = 9210.0 nM 5.04
CHEMBL1770200 IC50 = 11990.0 nM 4.92
CHEMBL1770204 IC50 = 16230.0 nM 4.79
CHEMBL1770199 IC50 > 25000.0 nM -
CHEMBL1770198 IC50 > 25000.0 nM -
CHEMBL1770197 IC50 > 25000.0 nM -
CHEMBL1770203 IC50 > 25000.0 nM -
CHEMBL1770202 IC50 > 25000.0 nM -
CHEMBL1770152 IC50 > 25000.0 nM -
CHEMBL1770196 IC50 > 25000.0 nM -
CHEMBL1770205 IC50 > 25000.0 nM -
CHEMBL1770206 IC50 > 25000.0 nM -
CHEMBL1770207 IC50 > 25000.0 nM -
CHEMBL1770208 IC50 > 25000.0 nM -
CHEMBL1770209 IC50 > 25000.0 nM -
CHEMBL1770211 IC50 > 25000.0 nM -
CHEMBL1770212 IC50 > 25000.0 nM -
CHEMBL1770213 IC50 > 25000.0 nM -
CHEMBL556249 IC50 > 25000.0 nM -