Assay Detail
Functional
CHEMBL1772425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay
40
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucose-dependent insulinotropic receptor (CHEMBL5263) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design of potent and selective GPR119 agonists for type II diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 7.46 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1771098 | — | — | 3 | 9.40 |
| CHEMBL1771104 | — | — | 1 | 9.10 |
| CHEMBL1771103 | — | — | 1 | 8.70 |
| CHEMBL1771082 | — | — | 1 | 8.70 |
| CHEMBL1771081 | — | — | 1 | 8.70 |
| CHEMBL1771102 | — | — | 1 | 8.40 |
| CHEMBL1771100 | — | — | 1 | 8.40 |
| CHEMBL1771101 | — | — | 1 | 8.22 |
| CHEMBL1771092 | — | — | 1 | 8.10 |
| CHEMBL1770161 | — | — | 1 | 8.10 |
| CHEMBL1771097 | — | — | 2 | 8.05 |
| CHEMBL1771094 | — | — | 1 | 8.00 |
| CHEMBL1771079 | — | — | 1 | 7.96 |
| CHEMBL1771093 | — | — | 1 | 7.96 |
| CHEMBL1771099 | — | — | 2 | 7.75 |
| CHEMBL1771080 | — | — | 1 | 7.51 |
| CHEMBL1771068 | — | — | 1 | 7.44 |
| CHEMBL1771091 | — | — | 1 | 7.39 |
| CHEMBL1771086 | — | — | 1 | 7.35 |
| CHEMBL1771096 | — | — | 1 | 7.19 |
| CHEMBL1771090 | — | — | 1 | 7.14 |
| CHEMBL1771095 | — | — | 1 | 7.09 |
| CHEMBL1771088 | — | — | 1 | 6.88 |
| CHEMBL1771070 | — | — | 1 | 6.88 |
| CHEMBL1771078 | — | — | 1 | 6.85 |
| CHEMBL1771073 | — | — | 1 | 6.78 |
| CHEMBL1771089 | — | — | 1 | 6.69 |
| CHEMBL1771084 | — | — | 1 | 6.62 |
| CHEMBL1771071 | — | — | 1 | 6.47 |
| CHEMBL1771076 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1771098 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1771104 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1771098 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1771082 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1771081 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1771103 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1771102 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1771100 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1771098 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1771101 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1770161 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1771092 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1771097 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1771094 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1771079 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1771093 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1771099 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1771097 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1771080 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1771068 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1771099 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1771091 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1771086 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1771096 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1771090 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1771095 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1771088 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL1771070 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1771078 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1771073 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1771089 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL1771084 | — | EC50 | = | 239.0 | nM | 6.62 |
| CHEMBL1771071 | — | EC50 | = | 341.0 | nM | 6.47 |
| CHEMBL1771076 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL1771072 | — | EC50 | = | 513.0 | nM | 6.29 |
| CHEMBL1771077 | — | EC50 | = | 523.0 | nM | 6.28 |
| CHEMBL1771083 | — | EC50 | = | 682.0 | nM | 6.17 |
| CHEMBL1771085 | — | EC50 | = | 887.0 | nM | 6.05 |
| CHEMBL1771067 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1771075 | — | EC50 | = | 2500.0 | nM | 5.60 |