Compound Detail
CHEMBL1771088
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Basic Information
| ChEMBL ID | CHEMBL1771088 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CQGOOXRESMDIBQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
2
Publications
0
Known Names
Molecular Properties
434.0
MW (Da)
4.27
ALogP
5
HBA
0
HBD
53.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor CHEMBL5652 | EC50 | 7.32 | 7.32 | 48.0 | 1 |
| Glucose-dependent insulinotropic receptor CHEMBL5263 | EC50 | 6.88 | 6.88 | 131.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 19.3 | uM.hr.Kg/mg | Mus musculus |
| CL | 2.0 | mL.min-1.kg-1 | Mus musculus |
| T1/2 | 13.5 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor | EC50 | = | 48.0 | nM | 7.32 | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 a... | 21273063 |
| Glucose-dependent insulinotropic receptor | EC50 | = | 131.0 | nM | 6.88 | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 a... | 21273063 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21273063 | 10.1016/j.bmcl.2010.12.086 | Mus musculus | 4 |
| 21273063 | 10.1016/j.bmcl.2010.12.086 | Glucose-dependent insulinotropic receptor | 2 |
Data from ChEMBL 36 via Core Engine