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Assay Detail

CHEMBL1772857

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB-0528 cells after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB-0528
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs.
Lu HF, Xie C, Chang J, Lin GQ, Sun X.
Eur J Med Chem (2011) 46 : 1743 -1748
PubMed 21396751 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 9.57 10.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1770954 1 10.59
CHEMBL503146 1 10.08
CHEMBL499248 1 9.68
CHEMBL501144 1 9.61
CHEMBL504290 1 9.55
CHEMBL1770953 1 9.40
CHEMBL3545252 DOCETAXEL 4.0 1 9.34
CHEMBL446326 1 9.30
CHEMBL510311 1 9.15
CHEMBL1770952 1 9.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1770954 IC50 = 0.02589 nM 10.59
CHEMBL503146 IC50 = 0.08342 nM 10.08
CHEMBL499248 IC50 = 0.2101 nM 9.68
CHEMBL501144 IC50 = 0.2476 nM 9.61
CHEMBL504290 IC50 = 0.282 nM 9.55
CHEMBL1770953 IC50 = 0.3969 nM 9.40
CHEMBL3545252 DOCETAXEL IC50 = 0.4536 nM 9.34
CHEMBL446326 IC50 = 0.5057 nM 9.30
CHEMBL510311 IC50 = 0.7076 nM 9.15
CHEMBL1770952 IC50 = 0.9146 nM 9.04