Assay Detail
Functional
CHEMBL1772859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug-resistant human KBR-0530 cells after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBR-0530 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.65 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446326 | — | — | 1 | 10.49 |
| CHEMBL499248 | — | — | 1 | 9.97 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.88 |
| CHEMBL510311 | — | — | 1 | 9.79 |
| CHEMBL1770952 | — | — | 1 | 9.63 |
| CHEMBL1770953 | — | — | 1 | 9.49 |
| CHEMBL1770954 | — | — | 1 | 9.48 |
| CHEMBL504290 | — | — | 1 | 9.48 |
| CHEMBL501144 | — | — | 1 | 9.17 |
| CHEMBL503146 | — | — | 1 | 9.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446326 | — | IC50 | = | 0.0322 | nM | 10.49 |
| CHEMBL499248 | — | IC50 | = | 0.1076 | nM | 9.97 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1317 | nM | 9.88 |
| CHEMBL510311 | — | IC50 | = | 0.1609 | nM | 9.79 |
| CHEMBL1770952 | — | IC50 | = | 0.2318 | nM | 9.63 |
| CHEMBL1770953 | — | IC50 | = | 0.3207 | nM | 9.49 |
| CHEMBL1770954 | — | IC50 | = | 0.3318 | nM | 9.48 |
| CHEMBL504290 | — | IC50 | = | 0.3321 | nM | 9.48 |
| CHEMBL501144 | — | IC50 | = | 0.6695 | nM | 9.17 |
| CHEMBL503146 | — | IC50 | = | 0.6941 | nM | 9.16 |