Assay Detail
Functional
CHEMBL1772861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug-resistant human HL60OR-0604-2 cells after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.39 | 10.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770954 | — | — | 1 | 10.81 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.94 |
| CHEMBL499248 | — | — | 1 | 9.72 |
| CHEMBL503146 | — | — | 1 | 9.39 |
| CHEMBL1770952 | — | — | 1 | 9.29 |
| CHEMBL504290 | — | — | 1 | 9.26 |
| CHEMBL510311 | — | — | 1 | 9.23 |
| CHEMBL446326 | — | — | 1 | 9.02 |
| CHEMBL1770953 | — | — | 1 | 8.68 |
| CHEMBL501144 | — | — | 1 | 8.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770954 | — | IC50 | = | 0.01545 | nM | 10.81 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.114 | nM | 9.94 |
| CHEMBL499248 | — | IC50 | = | 0.1909 | nM | 9.72 |
| CHEMBL503146 | — | IC50 | = | 0.4099 | nM | 9.39 |
| CHEMBL1770952 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL504290 | — | IC50 | = | 0.5539 | nM | 9.26 |
| CHEMBL510311 | — | IC50 | = | 0.584 | nM | 9.23 |
| CHEMBL446326 | — | IC50 | = | 0.9583 | nM | 9.02 |
| CHEMBL1770953 | — | IC50 | = | 2.085 | nM | 8.68 |
| CHEMBL501144 | — | IC50 | = | 2.973 | nM | 8.53 |