Assay Detail
Functional
CHEMBL1775311
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Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as stimulation of intracellular cAMP production after 30 mins of washing by wash-off assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.82 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230490 | — | — | 1 | 8.96 |
| CHEMBL1773267 | — | — | 1 | 8.62 |
| CHEMBL1773266 | — | — | 1 | 8.24 |
| CHEMBL1773197 | — | — | 1 | 8.09 |
| CHEMBL1773262 | — | — | 1 | 8.00 |
| CHEMBL1773264 | — | — | 1 | 7.89 |
| CHEMBL1773198 | — | — | 1 | 7.82 |
| CHEMBL1773196 | — | — | 1 | 7.77 |
| CHEMBL1773263 | — | — | 1 | 6.94 |
| CHEMBL1773074 | — | — | 1 | 6.89 |
| CHEMBL1773265 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230490 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1773267 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1773266 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1773197 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL1773262 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1773264 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1773198 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1773196 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1773263 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1773074 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL1773265 | — | EC50 | = | 173.0 | nM | 6.76 |