Assay Detail
Binding
CHEMBL1775313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.06 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773196 | — | — | 1 | 10.04 |
| CHEMBL1773197 | — | — | 1 | 9.56 |
| CHEMBL1773267 | — | — | 1 | 9.52 |
| CHEMBL1773198 | — | — | 1 | 9.40 |
| CHEMBL1773264 | — | — | 1 | 9.20 |
| CHEMBL1773074 | — | — | 1 | 9.12 |
| CHEMBL1773266 | — | — | 1 | 9.00 |
| CHEMBL1773263 | — | — | 1 | 8.84 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.44 |
| CHEMBL1773265 | — | — | 1 | 8.33 |
| CHEMBL1773262 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773196 | — | Ki | = | 0.091 | nM | 10.04 |
| CHEMBL1773197 | — | Ki | = | 0.276 | nM | 9.56 |
| CHEMBL1773267 | — | Ki | = | 0.305 | nM | 9.52 |
| CHEMBL1773198 | — | Ki | = | 0.397 | nM | 9.40 |
| CHEMBL1773264 | — | Ki | = | 0.634 | nM | 9.20 |
| CHEMBL1773074 | — | Ki | = | 0.765 | nM | 9.12 |
| CHEMBL1773266 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL1773263 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL1382 | TOLTERODINE | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1773265 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL1773262 | — | Ki | = | 6.1 | nM | 8.21 |