Assay Detail
Binding
CHEMBL1775351
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Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.54 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774147 | — | — | 1 | 6.17 |
| CHEMBL1256993 | — | — | 1 | 6.17 |
| CHEMBL1774153 | — | — | 1 | 5.96 |
| CHEMBL1774264 | — | — | 1 | 5.88 |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | 5.25 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 5.11 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774147 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1256993 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1774153 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1774264 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL430 | GEMIFLOXACIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 62000.0 | nM | 4.21 |