Assay Detail
Functional
CHEMBL1775381
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Growth inhibition of human GIST882 cells expressing c-Kit after 96 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GIST882 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.19 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 5.77 |
| CHEMBL1773218 | — | — | 1 | 5.39 |
| CHEMBL1773217 | — | — | 1 | 5.30 |
| CHEMBL1773219 | — | — | 1 | 4.86 |
| CHEMBL1773221 | — | — | 1 | 4.64 |
| CHEMBL1773220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1773218 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1773217 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1773219 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL1773221 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1773220 | — | IC50 | > | 50000.0 | nM | - |