Assay Detail
Binding
CHEMBL1775423
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Displacement of [3H]prazosin from human adrenergic alpha1 expressed in CHO-K1 cells after 30 mins by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.85 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559664 | — | — | 1 | 6.37 |
| CHEMBL1774500 | — | — | 1 | 5.32 |
| CHEMBL1774490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559664 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1774500 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1774490 | — | IC50 | > | 10000.0 | nM | - |