Assay Detail
Binding
CHEMBL1775596
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Inhibition of human AChE using acetylthiocholine iodide as substrate by Ellman's assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.66 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.64 |
| CHEMBL1773483 | — | — | 1 | 7.62 |
| CHEMBL1773482 | — | — | 1 | 7.60 |
| CHEMBL1773485 | — | — | 1 | 7.17 |
| CHEMBL1773484 | — | — | 1 | 6.97 |
| CHEMBL1773491 | — | — | 1 | 6.96 |
| CHEMBL1773492 | — | — | 1 | 6.89 |
| CHEMBL1773486 | — | — | 1 | 6.84 |
| CHEMBL1773487 | — | — | 1 | 6.84 |
| CHEMBL1773478 | — | — | 1 | 6.68 |
| CHEMBL1773489 | — | — | 1 | 6.68 |
| CHEMBL1773481 | — | — | 1 | 6.66 |
| CHEMBL1773488 | — | — | 1 | 6.59 |
| CHEMBL1773479 | — | — | 1 | 6.26 |
| CHEMBL1773480 | — | — | 1 | 6.14 |
| CHEMBL1773490 | — | — | 1 | 6.09 |
| CHEMBL514966 | — | — | 1 | 5.74 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1773483 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1773482 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1773485 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1773484 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL1773491 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1773492 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1773486 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1773487 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1773478 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1773489 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1773481 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL1773488 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1773479 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1773480 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1773490 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL514966 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 32000.0 | nM | 4.50 |