Assay Detail
Binding
CHEMBL1775597
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Inhibition of human BChE using butyrylthiocholine iodide as substrate by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.70 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.13 |
| CHEMBL1773489 | — | — | 1 | 5.01 |
| CHEMBL1773487 | — | — | 1 | 4.98 |
| CHEMBL1773483 | — | — | 1 | 4.96 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.88 |
| CHEMBL1773484 | — | — | 1 | 4.68 |
| CHEMBL1773488 | — | — | 1 | 4.66 |
| CHEMBL1773490 | — | — | 1 | 4.64 |
| CHEMBL1773491 | — | — | 1 | 4.62 |
| CHEMBL1773486 | — | — | 1 | 4.47 |
| CHEMBL1773482 | — | — | 1 | 4.46 |
| CHEMBL1773485 | — | — | 1 | 4.41 |
| CHEMBL1773481 | — | — | 1 | 4.17 |
| CHEMBL1773480 | — | — | 1 | - |
| CHEMBL1773492 | — | — | 1 | - |
| CHEMBL514966 | — | — | 1 | - |
| CHEMBL1773479 | — | — | 1 | - |
| CHEMBL1773478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1773489 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1773487 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1773483 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1773484 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1773488 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1773490 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1773491 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL1773486 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1773482 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1773485 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1773481 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL1773480 | — | IC50 | = | 179000.0 | nM | - |
| CHEMBL1773492 | — | IC50 | = | 209000.0 | nM | - |
| CHEMBL514966 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1773479 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL1773478 | — | IC50 | = | 144000.0 | nM | - |