Assay Detail
Binding
CHEMBL1775602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18F]fluorobenzothiazoles as a potential positron emission tomography imaging probe for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.08 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774642 | — | — | 1 | 8.26 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.24 |
| CHEMBL1774643 | — | — | 1 | 8.23 |
| CHEMBL284575 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774642 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1774643 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL284575 | — | Ki | = | 26.2 | nM | 7.58 |