Assay Detail
Functional
CHEMBL1776269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fMLP/CB-activated human neutrophil degranulation assessed as inhibition of elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as a substrate after 5 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.24 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 6.12 |
| CHEMBL1773981 | TAIBAIENOSIDE I | — | 1 | 5.87 |
| CHEMBL1773986 | — | — | 1 | 5.73 |
| CHEMBL1773984 | — | — | 1 | 5.71 |
| CHEMBL1095348 | CHIKUSETSUSAPONIN IVA | — | 1 | 5.32 |
| CHEMBL502145 | — | — | 1 | 5.14 |
| CHEMBL1288833 | PSEUDOGINSENOSIDE RT1 METHYL ESTER | — | 1 | 5.11 |
| CHEMBL510111 | — | — | 1 | 5.02 |
| CHEMBL1288834 | PSEUDOGINSENOSIDE RT1 | — | 1 | 4.35 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.02 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1773981 | TAIBAIENOSIDE I | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1773986 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1773984 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL1095348 | CHIKUSETSUSAPONIN IVA | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL502145 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL1288833 | PSEUDOGINSENOSIDE RT1 METHYL ESTER | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL510111 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL1288834 | PSEUDOGINSENOSIDE RT1 | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | - | — | - |