Assay Detail
Functional
CHEMBL1776543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells over expressing RSK2 after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.95 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 6.08 |
| CHEMBL529177 | — | — | 1 | 4.52 |
| CHEMBL1775067 | — | — | 1 | 4.25 |
| CHEMBL1775068 | — | — | 1 | - |
| CHEMBL1775069 | — | — | 1 | - |
| CHEMBL1775070 | — | — | 1 | - |
| CHEMBL1775071 | — | — | 1 | - |
| CHEMBL1775072 | — | — | 1 | - |
| CHEMBL1775073 | — | — | 1 | - |
| CHEMBL1775074 | — | — | 1 | - |
| CHEMBL1775075 | — | — | 1 | - |
| CHEMBL1775076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL529177 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL1775067 | — | IC50 | = | 56230.0 | nM | 4.25 |
| CHEMBL1775068 | — | IC50 | - | — | - | |
| CHEMBL1775069 | — | IC50 | - | — | - | |
| CHEMBL1775070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775071 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775072 | — | IC50 | - | — | - | |
| CHEMBL1775073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1775074 | — | IC50 | - | — | - | |
| CHEMBL1775075 | — | IC50 | - | — | - | |
| CHEMBL1775076 | — | IC50 | - | — | - |