Assay Detail
Functional
CHEMBL1776559
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Immunosuppressive activity in BALB/c/C57BL/6 mouse T cells assessed as inhibition of alloantigen-induced cell proliferation after 96 hrs by measuring [3H]thymidine uptake by mixed lymphocyte reaction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.75 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55076 | MYRIOCIN | — | 1 | 8.52 |
| CHEMBL141579 | — | — | 1 | 8.23 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 8.21 |
| CHEMBL138862 | — | — | 1 | 7.92 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.85 |
| CHEMBL343090 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55076 | MYRIOCIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL141579 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL138862 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL343090 | — | IC50 | = | 1630.0 | nM | 5.79 |