Assay Detail
Binding
CHEMBL1776952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.84 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774161 | — | — | 1 | 8.28 |
| CHEMBL1774162 | — | — | 1 | 8.27 |
| CHEMBL1774163 | — | — | 1 | 8.27 |
| CHEMBL1774157 | — | — | 1 | 8.22 |
| CHEMBL1774031 | — | — | 1 | 8.19 |
| CHEMBL1774160 | — | — | 1 | 8.18 |
| CHEMBL1774154 | — | — | 1 | 8.12 |
| CHEMBL1774158 | — | — | 1 | 8.10 |
| CHEMBL1774164 | — | — | 1 | 8.09 |
| CHEMBL1774156 | — | — | 1 | 8.00 |
| CHEMBL1774165 | — | — | 1 | 7.85 |
| CHEMBL1773083 | — | — | 1 | 7.80 |
| CHEMBL1774159 | — | — | 1 | 7.77 |
| CHEMBL1774166 | — | — | 1 | 6.55 |
| CHEMBL481422 | — | — | 1 | 5.91 |
| CHEMBL1774155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774161 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1774162 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1774163 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1774157 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1774031 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1774160 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1774154 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1774158 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL1774164 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1774156 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1774165 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1773083 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1774159 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1774166 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL481422 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1774155 | — | IC50 | > | 50000.0 | nM | - |