Assay Detail
Binding
CHEMBL1777019
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Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.75 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147511 | — | — | 1 | 8.38 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.23 |
| CHEMBL1774949 | — | — | 1 | 8.10 |
| CHEMBL1774946 | — | — | 1 | 8.09 |
| CHEMBL146756 | — | — | 1 | 8.03 |
| CHEMBL33986 | BUTORPHANOL | 4.0 | 1 | 7.92 |
| CHEMBL1774947 | — | — | 1 | 7.89 |
| CHEMBL1773091 | — | — | 1 | 7.85 |
| CHEMBL242756 | — | — | 1 | 7.54 |
| CHEMBL1774950 | — | — | 1 | 7.46 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 7.42 |
| CHEMBL1774952 | — | — | 1 | 7.41 |
| CHEMBL1774948 | — | — | 1 | 7.41 |
| CHEMBL1774951 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147511 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1774949 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1774946 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL146756 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL33986 | BUTORPHANOL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1774947 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1773091 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL242756 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1774950 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL80 | NALOXONE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1774952 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1774948 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1774951 | — | Ki | = | 170.0 | nM | 6.77 |