Assay Detail
Functional
CHEMBL1777141
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Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.44 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774160 | — | — | 1 | 8.92 |
| CHEMBL1774158 | — | — | 1 | 8.80 |
| CHEMBL1774159 | — | — | 1 | 8.57 |
| CHEMBL1774154 | — | — | 1 | 8.48 |
| CHEMBL1774031 | — | — | 1 | 8.24 |
| CHEMBL1774157 | — | — | 1 | 7.97 |
| CHEMBL1774163 | — | — | 1 | 7.71 |
| CHEMBL1774161 | — | — | 1 | 6.97 |
| CHEMBL1774156 | — | — | 1 | 6.82 |
| CHEMBL1773083 | — | — | 1 | 6.82 |
| CHEMBL1774164 | — | — | 1 | 6.76 |
| CHEMBL1774165 | — | — | 1 | 6.65 |
| CHEMBL1774162 | — | — | 1 | 6.58 |
| CHEMBL481422 | — | — | 1 | 6.20 |
| CHEMBL1774166 | — | — | 1 | 6.17 |
| CHEMBL1774155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774160 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1774158 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1774159 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1774154 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1774031 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1774157 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL1774163 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL1774161 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL1774156 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1773083 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL1774164 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL1774165 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1774162 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL481422 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL1774166 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL1774155 | — | IC50 | > | 100000.0 | nM | - |