Assay Detail
Binding
CHEMBL1777448
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Binding affinity to Influenza A virus (A/Udorn/72) transmembrane domain of matrix protein 2 (22 to 46) at pH 7.4 by circular dichroism analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.73 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.41 |
| CHEMBL450375 | — | — | 1 | 5.33 |
| CHEMBL1774319 | — | — | 1 | 4.13 |
| CHEMBL472275 | — | — | 1 | 4.04 |
| CHEMBL1774321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL450375 | — | Kd | = | 4700.0 | nM | 5.33 |
| CHEMBL1774319 | — | Kd | = | 74900.0 | nM | 4.13 |
| CHEMBL472275 | — | Kd | = | 91600.0 | nM | 4.04 |
| CHEMBL1774321 | — | Kd | = | 231500.0 | nM | - |