Compound Detail
CHEMBL1774321
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Basic Information
| ChEMBL ID | CHEMBL1774321 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCDNHDZDOGCFDG-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1789740 |
| Active Moiety | CHEMBL1789740 |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
225.3
MW (Da)
1.60
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.66
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.62
Kd 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Matrix protein 2 CHEMBL1932894 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Matrix protein 2 | IC50 | = | 24000.0 | nM | 4.62 | Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expresse... | 21466220 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21466220 | 10.1021/jm101334y | Matrix protein 2 | 6 |
| 21466220 | 10.1021/jm101334y | Influenza A virus | 1 |
| 21466220 | 10.1021/jm101334y | Unchecked | 1 |
| 21466220 | 10.1021/jm101334y | MDCK | 1 |
Data from ChEMBL 36 via Core Engine