Assay Detail
Binding
CHEMBL1777645
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Inhibition of RSK2 after 60 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.63 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 8.00 |
| CHEMBL529177 | — | — | 1 | 6.50 |
| CHEMBL1775067 | — | — | 1 | 6.32 |
| CHEMBL1775068 | — | — | 1 | 6.02 |
| CHEMBL1775069 | — | — | 1 | 5.97 |
| CHEMBL1775070 | — | — | 1 | 5.86 |
| CHEMBL1775071 | — | — | 1 | 5.80 |
| CHEMBL1775072 | — | — | 1 | 5.54 |
| CHEMBL1775073 | — | — | 1 | 5.52 |
| CHEMBL1775074 | — | — | 1 | 5.46 |
| CHEMBL1775075 | — | — | 1 | 5.26 |
| CHEMBL1775076 | — | — | 1 | 5.15 |
| CHEMBL1775077 | — | — | 1 | 5.00 |
| CHEMBL1775078 | — | — | 1 | 4.88 |
| CHEMBL1775079 | — | — | 1 | 4.84 |
| CHEMBL1775080 | — | — | 1 | 4.82 |
| CHEMBL1775081 | — | — | 1 | 4.79 |
| CHEMBL515414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL529177 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1775067 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1775068 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1775069 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1775070 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL1775071 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1775072 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1775073 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL1775074 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL1775075 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1775076 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL1775077 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL1775078 | — | IC50 | = | 13180.0 | nM | 4.88 |
| CHEMBL1775079 | — | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL1775080 | — | IC50 | = | 15140.0 | nM | 4.82 |
| CHEMBL1775081 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL515414 | — | IC50 | = | 15.0 | nM | - |