Assay Detail
Functional
CHEMBL1780271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PGD2-induced eosinophil shape change in human whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New indole amide derivatives as potent CRTH2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.63 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1778387 | — | — | 1 | 9.02 |
| CHEMBL1778524 | — | — | 1 | 9.00 |
| CHEMBL1778388 | — | — | 1 | 8.85 |
| CHEMBL561132 | MK-7246 | 1.0 | 1 | 8.66 |
| CHEMBL1778525 | — | — | 1 | 8.62 |
| CHEMBL1778523 | — | — | 1 | 8.36 |
| CHEMBL1778506 | — | — | 1 | 8.32 |
| CHEMBL1778522 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1778387 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL1778524 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1778388 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL561132 | MK-7246 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1778525 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1778523 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1778506 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1778522 | — | IC50 | = | 6.0 | nM | 8.22 |