Assay Detail
Binding
CHEMBL1780333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE8A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (CHEMBL4640) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.74 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779976 | — | — | 1 | 8.74 |
| CHEMBL1779978 | — | — | 1 | 8.74 |
| CHEMBL1779984 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779976 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1779978 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1779984 | — | IC50 | = | 1.8 | nM | 8.74 |