High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O60658. Use UniProt O60658 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60658 as the stable identity anchor, then attach disease evidence before program review.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Review this target as High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, mapped to UniProt O60658. Sequence length is 829 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A as ChEMBL target CHEMBL4640, mapped to UniProt O60658. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O60658 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| UniProt Accession | O60658 |
| Component Type | Protein |
| Sequence Length | 829 aa |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Review this target as High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, mapped to UniProt O60658. Sequence length is 829 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5169811 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL5285855 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1779976 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL1779978 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL1779984 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL2070735 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL5723345 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL4762103 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3646900 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4753446 | 7.58 | IC50 | 26.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 78 | 20 | 6.5 |
| cell-based format | 18 | 5 | 5.2 |
| assay format | 10 | 16 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 0 | — |
| cell-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 8.9 |