Compound Detail
CHEMBL4753446
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Basic Information
| ChEMBL ID | CHEMBL4753446 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MMMUNMQNRGXDNZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
354.8
MW (Da)
2.71
ALogP
7
HBA
1
HBD
91.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A CHEMBL4640 | IC50 | 7.58 | 7.58 | 26.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | IC50 | = | 26.0 | nM | 7.58 | Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escheri... | 33291877 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33291877 | 10.1021/acs.jmedchem.0c01573 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | 1 |
Data from ChEMBL 36 via Core Engine