Assay Detail
Binding
CHEMBL1780591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.66 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779410 | — | — | 1 | 10.52 |
| CHEMBL1779409 | — | — | 1 | 10.52 |
| CHEMBL1779407 | — | — | 1 | 10.40 |
| CHEMBL1779406 | — | — | 1 | 10.10 |
| CHEMBL1779408 | — | — | 1 | 9.59 |
| CHEMBL1779405 | — | — | 1 | 9.09 |
| CHEMBL1779417 | — | — | 1 | 8.92 |
| CHEMBL1779400 | — | — | 1 | 8.89 |
| CHEMBL1779420 | — | — | 1 | 8.89 |
| CHEMBL582857 | NELIVAPTAN | 2.0 | 1 | 8.77 |
| CHEMBL1779418 | — | — | 1 | 8.70 |
| CHEMBL1779402 | — | — | 1 | 8.68 |
| CHEMBL1779401 | — | — | 1 | 8.42 |
| CHEMBL1779419 | — | — | 1 | 8.41 |
| CHEMBL1779404 | — | — | 1 | 8.25 |
| CHEMBL1779416 | — | — | 1 | 7.70 |
| CHEMBL1779403 | — | — | 1 | 7.58 |
| CHEMBL1779415 | — | — | 1 | 7.00 |
| CHEMBL1779414 | — | — | 1 | 6.56 |
| CHEMBL1779412 | — | — | 1 | 6.11 |
| CHEMBL1779411 | — | — | 1 | - |
| CHEMBL1779413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779410 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1779409 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1779407 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL1779406 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL1779408 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL1779405 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL1779417 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1779400 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1779420 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL582857 | NELIVAPTAN | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1779418 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1779402 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1779401 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1779419 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1779404 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL1779416 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1779403 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1779415 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL1779414 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL1779412 | — | Ki | = | 786.0 | nM | 6.11 |
| CHEMBL1779411 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1779413 | — | Ki | > | 10000.0 | nM | - |