Assay Detail
Binding
CHEMBL1780594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled oxytocin from human oxytocin receptor expressed in CHO cells by scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.32 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779407 | — | — | 1 | 8.15 |
| CHEMBL1779409 | — | — | 1 | 7.77 |
| CHEMBL1779410 | — | — | 1 | 7.70 |
| CHEMBL582857 | NELIVAPTAN | 2.0 | 1 | 7.60 |
| CHEMBL1779406 | — | — | 1 | 7.55 |
| CHEMBL1779408 | — | — | 1 | 7.54 |
| CHEMBL1779400 | — | — | 1 | 7.38 |
| CHEMBL1779404 | — | — | 1 | 7.35 |
| CHEMBL1779405 | — | — | 1 | 7.35 |
| CHEMBL1779401 | — | — | 1 | 7.21 |
| CHEMBL1779420 | — | — | 1 | 7.05 |
| CHEMBL1779418 | — | — | 1 | 6.94 |
| CHEMBL1779419 | — | — | 1 | 6.87 |
| CHEMBL1779417 | — | — | 1 | 6.77 |
| CHEMBL1779403 | — | — | 1 | 6.57 |
| CHEMBL1779402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779407 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1779409 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1779410 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL582857 | NELIVAPTAN | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1779406 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1779408 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1779400 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL1779404 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL1779405 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL1779401 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1779420 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL1779418 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1779419 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL1779417 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL1779403 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL1779402 | — | Ki | - | — | - |