Assay Detail
Binding
CHEMBL1780797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Voltage-dependent L-type calcium channel in rat thoracic aorta ring
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.40 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | 8.96 |
| CHEMBL508181 | — | — | 1 | 7.34 |
| CHEMBL451812 | — | — | 3 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL508181 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL451812 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL451812 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL451812 | — | IC50 | = | 13200.0 | nM | 4.88 |