Assay Detail
Binding
CHEMBL1780860
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Inhibition of LPS-induced NF-kappaB-dependent reporter gene transcription in androgen-insensitive human PC3 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phenolic compounds with NF-κB inhibitory effects from the fungus Phellinus baumii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.32 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1780032 | METHYLPHELLIGRIN B | — | 1 | 4.65 |
| CHEMBL1780033 | — | — | 1 | 4.65 |
| CHEMBL1780030 | — | — | 1 | 4.44 |
| CHEMBL1780031 | — | — | 1 | 4.44 |
| CHEMBL1780025 | PHELLIBAUMIN B | — | 1 | 4.38 |
| CHEMBL1780024 | PHELLIBAUMIN A | — | 1 | 4.28 |
| CHEMBL1780028 | PHELLIBAUMIN E | — | 1 | 4.28 |
| CHEMBL1780034 | PHELLIGRIN A | — | 1 | 4.26 |
| CHEMBL1780121 | — | — | 1 | 4.26 |
| CHEMBL1780026 | PHELLIBAUMIN C | — | 1 | 4.21 |
| CHEMBL226019 | INTERFUNGIN B | — | 1 | 4.15 |
| CHEMBL1780027 | PHELLIBAUMIN D | — | 1 | 4.13 |
| CHEMBL376755 | PHELLIGRIDIN H | — | 1 | 4.07 |
| CHEMBL1780029 | PHELLIGRIDIMER A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1780032 | METHYLPHELLIGRIN B | IC50 | = | 22460.0 | nM | 4.65 |
| CHEMBL1780033 | — | IC50 | = | 22460.0 | nM | 4.65 |
| CHEMBL1780030 | — | IC50 | = | 36440.0 | nM | 4.44 |
| CHEMBL1780031 | — | IC50 | = | 36440.0 | nM | 4.44 |
| CHEMBL1780025 | PHELLIBAUMIN B | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL1780024 | PHELLIBAUMIN A | IC50 | = | 52960.0 | nM | 4.28 |
| CHEMBL1780028 | PHELLIBAUMIN E | IC50 | = | 52920.0 | nM | 4.28 |
| CHEMBL1780034 | PHELLIGRIN A | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL1780121 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL1780026 | PHELLIBAUMIN C | IC50 | = | 62280.0 | nM | 4.21 |
| CHEMBL226019 | INTERFUNGIN B | IC50 | = | 71190.0 | nM | 4.15 |
| CHEMBL1780027 | PHELLIBAUMIN D | IC50 | = | 74620.0 | nM | 4.13 |
| CHEMBL376755 | PHELLIGRIDIN H | IC50 | = | 84900.0 | nM | 4.07 |
| CHEMBL1780029 | PHELLIGRIDIMER A | IC50 | - | — | - |