Compound Detail
CHEMBL226019
INTERFUNGIN B Enter ChEMBL ID:
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CC(=O)/C(=C\c1ccc(O)c(O)c1)c1c(O)cc(/C=C/c2ccc(O)c(O)c2)oc1=O
Basic Information
| ChEMBL ID | CHEMBL226019 |
| Name | INTERFUNGIN B |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLJCBBHVLOHCCV-DVTHBBLZSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
422.4
MW (Da)
3.47
ALogP
8
HBA
5
HBD
148.4
PSA (Ų)
0.31
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.75 | 5.355 | 1800.0 | 2 |
| Radical scavenging activity CHEMBL613712 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.15 | 4.15 | 71190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 1800.0 | nM | 5.75 | Antioxidant activity assessed as superoxide radical anion scavenging activity | 17387019 |
| Radical scavenging activity | IC50 | = | 2500.0 | nM | 5.6 | Antioxidant activity assessed as DPPH radical scavenging activity | 17387019 |
| NON-PROTEIN TARGET | IC50 | = | 11100.0 | nM | 4.96 | Antioxidant activity assessed as ABTS radical scavenging activity | 17387019 |
| Unchecked | IC50 | = | 71190.0 | nM | 4.15 | Inhibition of LPS-induced NF-kappaB-dependent reporter gene transcription in and... | 21531558 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17387019 | 10.1016/j.bmc.2007.03.039 | NON-PROTEIN TARGET | 2 |
| 17387019 | 10.1016/j.bmc.2007.03.039 | Radical scavenging activity | 1 |
| 21531558 | 10.1016/j.bmcl.2011.04.025 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine