Assay Detail
Functional
CHEMBL1781142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex vivo inhibition of LPS-induced TNF-alpha production in po dosed Hanover Wistar rat administered 0.5 hr before challenge measured 1.5 hrs after challenge
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 1 | - | - |
| EC50 | 1 | 6.12 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236810 | — | — | 2 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236810 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1236810 | — | ED50 | = | 1.5 | mg.kg-1 | - |