Assay Detail
Functional
CHEMBL1781269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Plasmodium falciparum K1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.15 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232057 | — | — | 1 | 9.30 |
| CHEMBL3216972 | — | — | 1 | 9.15 |
| CHEMBL48217 | DAPI | — | 1 | 8.52 |
| CHEMBL3216515 | — | — | 1 | 8.51 |
| CHEMBL3216973 | — | — | 1 | 8.48 |
| CHEMBL3216091 | — | — | 1 | 8.42 |
| CHEMBL3217179 | — | — | 1 | 8.23 |
| CHEMBL3216750 | — | — | 1 | 7.85 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.81 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.33 |
| CHEMBL1780243 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232057 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3216972 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL48217 | DAPI | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3216515 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3216973 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3216091 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3217179 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3216750 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL1780243 | — | IC50 | = | 858.0 | nM | 6.07 |