Assay Detail
Functional
CHEMBL1781474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of viral DNA replication after 4 days by RT-PCR analysis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.35 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.48 |
| CHEMBL1779155 | — | — | 1 | 6.40 |
| CHEMBL1779299 | — | — | 1 | 5.96 |
| CHEMBL1779162 | — | — | 1 | 5.92 |
| CHEMBL1779160 | — | — | 1 | 5.46 |
| CHEMBL1779161 | — | — | 1 | 5.41 |
| CHEMBL1779180 | — | — | 1 | 5.28 |
| CHEMBL1779176 | — | — | 1 | 5.27 |
| CHEMBL1779156 | — | — | 1 | 5.22 |
| CHEMBL1779173 | — | — | 1 | 5.12 |
| CHEMBL1779177 | — | — | 1 | 5.08 |
| CHEMBL1779174 | — | — | 1 | 5.03 |
| CHEMBL1779298 | — | — | 1 | 5.00 |
| CHEMBL1779154 | — | — | 1 | 4.91 |
| CHEMBL1779158 | — | — | 1 | 4.89 |
| CHEMBL1779164 | — | — | 1 | 4.75 |
| CHEMBL1779182 | — | — | 1 | 4.70 |
| CHEMBL1779300 | — | — | 1 | - |
| CHEMBL1779166 | — | — | 1 | - |
| CHEMBL1779175 | — | — | 1 | - |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | - |
| CHEMBL142936 | DIETHYLTRYPTAMINE | — | 1 | - |
| CHEMBL1779153 | — | — | 1 | - |
| CHEMBL1779157 | — | — | 1 | - |
| CHEMBL1779159 | — | — | 1 | - |
| CHEMBL1779163 | — | — | 1 | - |
| CHEMBL1779165 | — | — | 1 | - |
| CHEMBL1779168 | — | — | 1 | - |
| CHEMBL1779167 | — | — | 1 | - |
| CHEMBL1779169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1779155 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1779299 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1779162 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1779160 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1779161 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1779180 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1779176 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1779156 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1779173 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1779177 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1779174 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1779298 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1779154 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL1779158 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1779164 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL1779182 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1779181 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1779179 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1779178 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1779172 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779170 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779167 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779168 | — | IC50 | - | — | - | |
| CHEMBL1779165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779159 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1779157 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779153 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142936 | DIETHYLTRYPTAMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779175 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1779166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1779300 | — | IC50 | > | 25000.0 | nM | - |