Assay Detail
Functional
CHEMBL1781692
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Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites after 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 6.30 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.11 |
| CHEMBL1545 | TIZOXANIDE | -1.0 | 1 | 5.91 |
| CHEMBL1779947 | — | — | 1 | 5.45 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.37 |
| CHEMBL1779948 | — | — | 1 | 5.10 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1545 | TIZOXANIDE | IC50 | = | 1229.0 | nM | 5.91 |
| CHEMBL1779947 | — | IC50 | = | 3515.0 | nM | 5.45 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL1779948 | — | IC50 | = | 8021.0 | nM | 5.10 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 11800.0 | nM | 4.93 |