Assay Detail
Binding
CHEMBL1781851
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Inhibition of human liver fructose-1,6-bisphosphatase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.41 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1778447 | — | — | 1 | 7.10 |
| CHEMBL1778449 | — | — | 1 | 6.89 |
| CHEMBL1778445 | — | — | 1 | 6.85 |
| CHEMBL1778448 | — | — | 1 | 6.77 |
| CHEMBL1778450 | — | — | 1 | 6.70 |
| CHEMBL1738935 | — | — | 1 | 6.66 |
| CHEMBL1778444 | — | — | 1 | 6.54 |
| CHEMBL595149 | — | — | 1 | 6.48 |
| CHEMBL1778443 | — | — | 1 | 6.48 |
| CHEMBL1778442 | — | — | 1 | 6.46 |
| CHEMBL1778558 | — | — | 1 | 6.46 |
| CHEMBL1778452 | — | — | 1 | 6.40 |
| CHEMBL1778555 | — | — | 1 | 6.38 |
| CHEMBL1778559 | — | — | 1 | 6.28 |
| CHEMBL1778557 | — | — | 1 | 6.28 |
| CHEMBL1778454 | — | — | 1 | 6.22 |
| CHEMBL1778441 | — | — | 1 | 6.19 |
| CHEMBL1778556 | — | — | 1 | 6.17 |
| CHEMBL1778453 | — | — | 1 | 6.12 |
| CHEMBL1778446 | — | — | 1 | 6.09 |
| CHEMBL1778560 | — | — | 1 | 5.77 |
| CHEMBL1778451 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1778447 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1778449 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1778445 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1778448 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1778450 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1738935 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1778444 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL595149 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1778443 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1778442 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1778558 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1778452 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1778555 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1778559 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1778557 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1778454 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1778441 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1778556 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1778453 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1778446 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1778560 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1778451 | — | IC50 | = | 1800.0 | nM | 5.75 |