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Assay Detail

CHEMBL1781853

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Reduction of glucose production in mouse hepatocytes after 6 hrs by glucose oxidase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Hepatocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatocyte (CHEMBL3140324)
Type CELL-LINE
Organism Mus musculus

Publication

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E.
Bioorg Med Chem Lett (2011) 21 : 3237 -3242
PubMed 21550236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 4.90 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1778556 1 5.57
CHEMBL1778555 1 5.40
CHEMBL1778447 1 5.30
CHEMBL1778559 1 5.29
CHEMBL1778557 1 5.23
CHEMBL1778445 1 5.21
CHEMBL1778451 1 5.16
CHEMBL1778448 1 5.10
CHEMBL1778449 1 5.10
CHEMBL1778453 1 5.10
CHEMBL1778558 1 5.08
CHEMBL1778454 1 5.05
CHEMBL1738935 1 4.92
CHEMBL1778444 1 4.89
CHEMBL1778450 1 4.85
CHEMBL1778560 1 4.72
CHEMBL1778443 1 4.64
CHEMBL1778442 1 4.39
CHEMBL595149 1 4.31
CHEMBL1778446 1 4.29
CHEMBL1778441 1 4.08
CHEMBL1778452 1 4.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1778556 EC50 = 2700.0 nM 5.57
CHEMBL1778555 EC50 = 4000.0 nM 5.40
CHEMBL1778447 EC50 = 5000.0 nM 5.30
CHEMBL1778559 EC50 = 5100.0 nM 5.29
CHEMBL1778557 EC50 = 5900.0 nM 5.23
CHEMBL1778445 EC50 = 6100.0 nM 5.21
CHEMBL1778451 EC50 = 7000.0 nM 5.16
CHEMBL1778448 EC50 = 8000.0 nM 5.10
CHEMBL1778449 EC50 = 8000.0 nM 5.10
CHEMBL1778453 EC50 = 8000.0 nM 5.10
CHEMBL1778558 EC50 = 8300.0 nM 5.08
CHEMBL1778454 EC50 = 8900.0 nM 5.05
CHEMBL1738935 EC50 = 12000.0 nM 4.92
CHEMBL1778444 EC50 = 13000.0 nM 4.89
CHEMBL1778450 EC50 = 14000.0 nM 4.85
CHEMBL1778560 EC50 = 19000.0 nM 4.72
CHEMBL1778443 EC50 = 23000.0 nM 4.64
CHEMBL1778442 EC50 = 41000.0 nM 4.39
CHEMBL595149 EC50 = 49000.0 nM 4.31
CHEMBL1778446 EC50 = 51000.0 nM 4.29
CHEMBL1778441 EC50 = 84000.0 nM 4.08
CHEMBL1778452 EC50 = 97000.0 nM 4.01