Assay Detail
Binding
CHEMBL1785088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli assessed as dissociation constant for binary enzyme-inhibitor complex using NAD+ substrate by Lineweaver-Burk plot method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (CHEMBL5926) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
Publication
Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.35 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455368 | ANACARDIC ACID | — | 1 | 5.40 |
| CHEMBL451726 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455368 | ANACARDIC ACID | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL451726 | — | Ki | = | 5000.0 | nM | 5.30 |