Assay Detail
Binding
CHEMBL1785145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat cortical hemispheres
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783889 | — | — | 1 | 8.30 |
| CHEMBL1783893 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783889 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1783893 | — | Ki | = | 10.0 | nM | 8.00 |